Coherent Raman Scattering (CRS) Microscopy

Select Publications and Bibliography

Validation

 

Orringer, D.A., Pandian, B., Niknafs, Y.S., Hollon, T.C., Boyle, J., Lewis, S., Garrard, M., Hervey-Jumper, S.L., Garton, H.J., Maher, C.O. and Heth, J.A., 2017. Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy. Nature biomedical engineering, 1(2), pp.1-13.

https://www.nature.com/articles/s41551-016-0027

 

Eichberg, D.G., Shah, A.H., Di, L., Semonche, A.M., Jimsheleishvili, G., Luther, E.M., Sarkiss, C.A., Levi, A.D., Gultekin, S.H., Komotar, R.J. and Ivan, M.E., 2019. Stimulated Raman histology for rapid and accurate intraoperative diagnosis of CNS tumors: prospective blinded study. Journal of neurosurgery, 134(1), pp.137-143.

https://thejns.org/doi/abs/10.3171/2019.9.JNS192075

 

Hollon, T.C., Lewis, S., Pandian, B., Niknafs, Y.S., Garrard, M.R., Garton, H., Maher, C.O., McFadden, K., Snuderl, M., Lieberman, A.P. and Muraszko, K., 2018. Rapid intraoperative diagnosis of pediatric brain tumors using stimulated Raman histology. Cancer research, 78(1), pp.278-289.

https://cancerres.aacrjournals.org/content/78/1/278

 

Luther, E., Matus, A., Eichberg, D.G., Shah, A.H. and Ivan, M., 2019. Stimulated Raman Histology for Intraoperative Guidance in the Resection of a Recurrent Atypical Spheno-orbital Meningioma: A Case Report and Review of Literature. Cureus, 11(10).

https://www.cureus.com/articles/24043-stimulated-raman-histology-for-intraoperative-guidance-in-the-resection-of-a-recurrent-atypical-spheno-orbital-meningioma-a-case-report-and-review-of-literature

Artificial Intelligence

Hollon, T.C., Pandian, B., Adapa, A.R., Urias, E., Save, A.V., Khalsa, S.S.S., Eichberg, D.G., D’Amico, R.S., Farooq, Z.U., Lewis, S. and Petridis, P.D., 2020. Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks. Nature medicine, 26(1), pp.52-58.

https://www.nature.com/articles/s41591-019-0715-9

 

Hollon, T.C., Pandian, B., Urias, E., Save, A.V., Adapa, A.R., Srinivasan, S., Jairath, N.K., Farooq, Z., Marie, T., Al-Holou, W.N. and Eddy, K., 2021. Rapid, label-free detection of diffuse glioma recurrence using intraoperative stimulated Raman histology and deep neural networks. Neuro-oncology, 23(1), pp.144-155.

https://doi.org/10.1093/neuonc/noaa162

 

Underlying Technology

 

Freudiger, C.W., Min, W., Saar, B.G., Lu, S., Holtom, G.R., He, C., Tsai, J.C., Kang, J.X. and Xie, X.S., 2008. Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science, 322(5909), pp.1857-1861.

https://science.sciencemag.org/content/322/5909/1857

 

Freudiger, C.W., Yang, W., Holtom, G.R., Peyghambarian, N., Xie, X.S. and Kieu, K.Q., 2014. Stimulated Raman scattering microscopy with a robust fibre laser source. Nature photonics, 8(2), pp.153-159.

https://www.nature.com/articles/nphoton.2013.360

 

Saar, B.G., Freudiger, C.W., Reichman, J., Stanley, C.M., Holtom, G.R. and Xie, X.S., 2010. Video-rate molecular imaging in vivo with stimulated Raman scattering. science, 330(6009), pp.1368-1370.

https://science.sciencemag.org/content/330/6009/1368

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